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Quiz about BreedSpecific Genetic Problems
Quiz about BreedSpecific Genetic Problems

Breed-Specific Genetic Problems Quiz


Breeds of dogs share a common gene pool that, unfortunately, often contains some bad genes. What do you know about genetic disorders specific to different breeds of dogs, and how to prevent them?

A multiple-choice quiz by crisw. Estimated time: 7 mins.
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Author
crisw
Time
7 mins
Type
Multiple Choice
Quiz #
199,305
Updated
Dec 03 21
# Qns
20
Difficulty
Very Difficult
Avg Score
8 / 20
Plays
2730
Awards
Top 20% Quiz
- -
Question 1 of 20
1. The Nova Scotia duck tolling retriever suffers from a hormonal malady unknown in other breeds. What is it? Hint


Question 2 of 20
2. Cyclic neutropenia, an immunodeficiency that leads to repeated infections and bleeding, is found only in a certain color of dog. Which one? Hint


Question 3 of 20
3. There are many genetic eye disorders in dogs. Which of the following is found primarily in the German shorthaired pointer? Hint


Question 4 of 20
4. Irish setters can suffer from a fatal immunodeficiency disease found only in this breed. What is it called? Hint


Question 5 of 20
5. Briards suffer from a type of blindness found only in their breed. What is it? Hint


Question 6 of 20
6. Fucosidosis, found only in the English springer spaniel, is an example of what type of disease? Hint


Question 7 of 20
7. Basset hounds can suffer from a disorder called basset hound thrombopathia. What does this disorder do? Hint


Question 8 of 20
8. Miniature schnauzers can suffer from a disorder called sick sinus syndrome. What body system does this disorder affect? Hint


Question 9 of 20
9. Progressive retinal atrophy is perhaps the most common genetic cause of blindness in dogs. In most breeds, PRA is inherited as an autosomal recessive trait. In which of the following breeds is PRA inherited as a X-linked recessive? Hint


Question 10 of 20
10. Irish setters suffer from a disease that is similar to celiac disease in humans. What is this disorder called? Hint


Question 11 of 20
11. As carnivores, most dogs tolerate cholesterol in their diet much better than humans do. However, one breed often has a genetic disorder that interferes with cholesterol metabolism. Which breed? Hint


Question 12 of 20
12. Labrador retrievers between 3 and 6 months of age which demonstrate stunted growth, weakness, a bunny-hopping gait and muscle atrophy may have what disorder? Hint


Question 13 of 20
13. Myotonia, a disorder that affects the ability of muscles to relax, is seen in what breed? Hint


Question 14 of 20
14. Beagle pain syndrome is a type of what disorder? Hint


Question 15 of 20
15. Collies can suffer from bullous pemphigoid; an immune system disorder. Which of the following is NOT true about this disorder? Hint


Question 16 of 20
16. Brittanies can have a condition called complement deficiency. What are affected dogs lacking? Hint


Question 17 of 20
17. In the 70s and 80s, David Vetter lived for 12 years in a plastic bubble that kept germs from him. His condition, severe combined immunodeficiency (SCID), is also seen in Arabian horses and what breed of dog? Hint


Question 18 of 20
18. Familial Shar-Pei fever (FSF) is an autosomal recessive disorder. Which of the following is NOT a symptom? Hint


Question 19 of 20
19. In Dalmatian bronzing syndrome, what does "bronzing" refer to? Hint


Question 20 of 20
20. Lethal acrodermatitis in the bull terrier is related to metabolism of what mineral? Hint



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Quiz Answer Key and Fun Facts
1. The Nova Scotia duck tolling retriever suffers from a hormonal malady unknown in other breeds. What is it?

Answer: Early-onset Addison's disease

Addison's disease, in which the adrenal glands do not work properly, is common in several breeds, but usually occurs in older dogs. In tollers, the mode of inheritance is unknown, but it is suspected to be polygenic. Tollers are the only breed in which the disease regularly appears in puppyhood, sometimes as early as 4 months.

In addition, while Addison's disease in older dogs is very treatable, the disease in young tollers often does not respond well to medication and is fatal.
2. Cyclic neutropenia, an immunodeficiency that leads to repeated infections and bleeding, is found only in a certain color of dog. Which one?

Answer: Gray collies

The disorder, an autosomal recessive, is often called "gray collie syndrome" for this reason. The disorder actually causes the color change in the coat to gray. It can be cured by a bone marrow transplant; this can actually cause the gray hairs to be replaced by normally-colored ones.
3. There are many genetic eye disorders in dogs. Which of the following is found primarily in the German shorthaired pointer?

Answer: Cone degeneration (CD2 mutation)

Cone degeneration causes the cone cells in the eye to deteriorate, leading to day blindness. There is a DNA test to determine whether or not a dog carries the genes for the disease. Cone degeneration, with this particular mutation, is found in Alaskan Malamutes as well as in the pointer.
4. Irish setters can suffer from a fatal immunodeficiency disease found only in this breed. What is it called?

Answer: Canine leukocyte adhesion deficiency

This autosomal recessive disorder leads to death at an early age from overwhelming infections. There is no effective treatment. A DNA test exists to detect carriers of the disorder.
5. Briards suffer from a type of blindness found only in their breed. What is it?

Answer: Congenital stationary night blindness

This disorder, in which the retinal pigment epithelium of the eye degenerates, was first discovered in Briards in Sweden. Gene therapy has been used to restore sight to affected dogs, and a DNA test exists to detect carriers of the disorder.
6. Fucosidosis, found only in the English springer spaniel, is an example of what type of disease?

Answer: Storage disease

Storage diseases result from abnormalities in lysosomal enzymes, preventing them from doing their job of removing certain substances from cells. This results in the storage of inappropriate materials in the cells, leading to cell damage, especially to nerve and brain cells. Fucosidosis in Springers is an autosomal recessive and causes gradual motor and mental decline, leading to death. A DNA test exists to detect carriers of the disorder.

Many different types are found in a variety of animals as well as humans.
7. Basset hounds can suffer from a disorder called basset hound thrombopathia. What does this disorder do?

Answer: Inhibits normal blood clotting

This autosomal recessive disorder affects the production of thrombin, a protein necessary for clotting, by platelets. Dogs with this disorder may bleed easily and their blood may fail to clot properly, thus leading to hemorrhage. Some dogs are only mildly affected, others have severe bleeding problems. There is no cure.
8. Miniature schnauzers can suffer from a disorder called sick sinus syndrome. What body system does this disorder affect?

Answer: Cardiovascular

Sick sinus syndrome is a malfunction of the sinus node, an area of the heart that acts as the heart's pacemaker. The mode of inheritance is unknown, and the treatment of choice is implantation of a pacemaker.
9. Progressive retinal atrophy is perhaps the most common genetic cause of blindness in dogs. In most breeds, PRA is inherited as an autosomal recessive trait. In which of the following breeds is PRA inherited as a X-linked recessive?

Answer: Siberian husky

As the disorder is X-linked, it is usually expressed in males, as males have only 1 X chromosome.
10. Irish setters suffer from a disease that is similar to celiac disease in humans. What is this disorder called?

Answer: Gluten-sensitive enteropathy

Dogs with this disorder cannot tolerate gluten; the protein found in wheat. They develop severe diarrhea and lose weight. The symptoms disappear when the dog is fed a wheat-free diet. The method of inheritance is unknown.
11. As carnivores, most dogs tolerate cholesterol in their diet much better than humans do. However, one breed often has a genetic disorder that interferes with cholesterol metabolism. Which breed?

Answer: Miniature schnauzer

Hyperlipoproteinemia, sometimes called hypercholesteremia, is common in the miniature schnauzer. When the dogs eat high-fat meals, they vomit and experience diarrhea and abdominal pain. The disease is treated by feeding a low-fat diet. The mode of inheritance is unknown.
12. Labrador retrievers between 3 and 6 months of age which demonstrate stunted growth, weakness, a bunny-hopping gait and muscle atrophy may have what disorder?

Answer: Labrador retriever myopathy

This autosomal recessive disorder may cause mild to severe disability. Signs usually do not worsen after 6-8 months of age, and dogs may improve with age.
13. Myotonia, a disorder that affects the ability of muscles to relax, is seen in what breed?

Answer: Chow chows

Dogs with myotonia have an awkward gait, difficulty moving, and stiff joints. Drug therapy may help affected dogs, and the condition usually does not worsen with age. This disorder is autosomal recessive in inheritance.
14. Beagle pain syndrome is a type of what disorder?

Answer: Meningitis

Usually seen in young beagles, beagle pain syndrome causes severe neck pain, depression and fever. The symptoms come and go. The disorder is treated with corticosteroids. The mode of inheritance is unknown.
15. Collies can suffer from bullous pemphigoid; an immune system disorder. Which of the following is NOT true about this disorder?

Answer: It causes susceptibility to respiratory infections

Dogs with bullous pemphigoid suffer from large blisters, especially in the mouth, groin and armpits, that often become infected. The mode of inheritance is not known.
16. Brittanies can have a condition called complement deficiency. What are affected dogs lacking?

Answer: Immune system proteins

Complements are proteins that are vital to the functioning of the immune system. In affected dogs, complement 3 (C-3) is lacking. These dogs suffer from infections and immune-mediated kidney failure. The pattern of inheritance is autosomal recessive. There is no cure, but a DNA test exists to detect carriers of the disorder.
17. In the 70s and 80s, David Vetter lived for 12 years in a plastic bubble that kept germs from him. His condition, severe combined immunodeficiency (SCID), is also seen in Arabian horses and what breed of dog?

Answer: Basset hounds

In both humans and bassets, SCID is an X-linked recessive. There is no effective treatment in dogs.
18. Familial Shar-Pei fever (FSF) is an autosomal recessive disorder. Which of the following is NOT a symptom?

Answer: Skin lesions

FSF involves an overproduction of interleukin-6, a cytokine that is involved with "priming" the immune response. It is a periodic disorder that comes and goes. It is treated with aspirin and with colchicine to help prevent amyloidosis, a severe side effect that can lead to kidney and liver failure.
19. In Dalmatian bronzing syndrome, what does "bronzing" refer to?

Answer: Bronze discoloration of the skin

Dalmatian bronzing syndrome is probably related to excess production of uric acid, a trait that all Dalmatians share. Affected dogs have a patchy hair coat, bronze discoloration of the skin, and a susceptibility to skin infections. The mode of inheritance is unknown.
20. Lethal acrodermatitis in the bull terrier is related to metabolism of what mineral?

Answer: Zinc

Bull terriers with lethal acrodermatitis cannot metabolize zinc properly. This leads to stunted growth, skin lesions, and infections. Affected dogs usually do not live past puppyhood. The disorder is autosomal recessive.
Source: Author crisw

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