Hmmm....of How The Grinch Stole Christmas Wikipedia comments: "The Whos of this book may or may not be the minuscule Whos of Horton Hears a Who; In the Broadway musical Seussical, the Grinch's Whos and Horton's are one and the same, the Grinch being microscopic and living on the dust speck as well. In the live-action movie, Whoville is located in a snowflake."
The Whos also appear in How the Grinch Stole Christmas! and Halloween is Grinch Night. The live-action The Grinch movie reinforces the idea that the Whos are microscopic by showing that the events in How The Grinch Stole Christmas! actually took place within a snowflake, but the 1966 animated TV special, like the original book, never mentions their size.
My only reference is in the original cartoons-- with Horton, He and the Wickersham brothers are "full" size animals where The Who's , Including Little Jo Jo Who, are microscopic.
The Grinch is "full" size; as shown for comparison when he is in the episode with The Cat in The Hat having a drive / picnic. The Cat in Hat as we all know is "full" size as shown with the children. Whereas Little Cindy Lou Who is the same "full" size as the Grinch in both original and remake.
Conclusion: Horton,Grinch and Cindy Lou Who = same "size". Horton, Grinch and Cindy Lou = 100x's larger than Jo Jo Who
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