In 1931, Alka Seltzer was introduced in the U.S.
Hub Beardsley, the president of Miles Laboratories, during a severe flu epidemic in winter 1928, had visited a local newspaper in Elkhart, Indiana where he learned from the editor, Tom Keene, that the staff seemed to be resistant to the illness. Keene explained that at the first sign of illness, he treated staff members with a combination of aspirin and baking soda.
Beardsley asked his chief chemist, Maurice Treneer, to develop an effervescent tablet with aspirin (acetylsalicylic acid) and sodium bicarbonate as the main ingredients. The resulting tablet seemed sufficiently effective to begin production, although Beardsley himself died in 1929. It was introduced in 1931, with heavy radio promotion.
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