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In the human body, what is the principal physiological function of the enzyme renin?

Question #150075. Asked by psnz.
Last updated Nov 03 2023.
Originally posted Nov 03 2023 9:33 PM.

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BigTriviaDawg star
Answer has 1 vote
BigTriviaDawg star
7 year member
1007 replies avatar

Answer has 1 vote.
Renin is a protein that helps control blood volume and by doing so blood pressure. About half of the blood pressure medications used in the United States involve the renin pathway in the kidneys.
The enzyme renin is secreted by pericytes in the vicinity of the afferent arterioles and similar microvessels of the kidney from specialized cells of the juxtaglomerular apparatus—the juxtaglomerular cells, in response to three stimuli:

1) A decrease in arterial blood pressure (that could be related to a decrease in blood volume) as detected by baroreceptors (pressure-sensitive cells). This is the most direct causal link between blood pressure and renin secretion (the other two methods operate via longer pathways).
2) A decrease in sodium load delivered to the distal tubule. This load is measured by the macula densa of the juxtaglomerular apparatus.
3) Sympathetic nervous system activity, which also controls blood pressure, acting through the beta 1 adrenergic receptors.
Human renin is secreted by at least 2 cellular pathways: a constitutive pathway for the secretion of the precursor prorenin and a regulated pathway for the secretion of mature renin.

link https://en.wikipedia.org/wiki/Renin


Response last updated by BigTriviaDawg on Nov 03 2023.
Nov 03 2023, 9:36 PM
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