Running with scissors is a stupid thing to do. It is also one of the things ALL parents have told their children to not do a million times. When one does it, not only are they being stupid but they are doing something they KNOW, beyond a shadow, that is stupid.
It is the blind common knowledge ignorance of what we know to be stupid and harmful.
There are also other "pop culture" meanings that I am unfamiliar with.
Running with Scissors - a 2002 book by Augusten Burroughs
Running with Scissors - a 2006 film starring Annette Bening and Gwyneth Paltrow, based on Augusten Burroughs' memoir
"Running with Scissors" - a song, written by Cindy Nelson for the movie, Running with Scissors
Running with Scissors - a 2001 poetry anthology edited by Canadian writers Andy Brown and Meg Sircom
Running With Scissors, Inc. - a video games developer based out of the USA
Running with Scissors - "Weird Al" Yankovic's 10th album released in 1999 https://en.wikipedia.org/wiki/Running_with_scissors
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