In an article from the AMA journal dated 2 January, 1978, Dr. Myron R. Shoenfeld advances the theory that Paganini was born with Marfan's Syndrome:
"The long, sinuous, hyperextensible fingers of his left hand gave his fingers an extraordinary range of motion and freedom of independent movement on the fingerboard, while the laxness of the wrist and shoulder joint of his right
upper extremity gave him the pliancy required for masterful bowing. The evidence for this hypothesis necessarily is inferential, but, I believe, convincing and even compelling.
"The range and independence of motion of the fingers was so extraordinary that it was widely suspected that he had undergone a surgical procedure to cut the bands that connect the tendons... However, it is unlikely that a talented musician at the dawn of his promising career would have so risked the safety of his hands, particularly given the primitive state of the surgical art at that time. Much more probable was that the facility was inborn."
Schoenfeld goes on to note that "the clinical features of Marfan's Syndrome were not even described until 1896, more than a half century after P.'s death," and that those symptoms would most likely not have been detectible to early 19th century medicine, anyway. "We cannot expect,
then, to find descriptions of these telltale complications of Marfan's Syndrome in P.'s life, even if indeed they had existed." However, Schoenfeld points to P.'s loss of his voice toward the end of his life, noting that it may have been "the hoarseness and aphonia caused by recurrent laryngeal nerve paralysis brought about by an expanding aneurysm of the aortic arch."
http://tafkac.org/celebrities/paganini_stories_myths.html