This isn't so much an internet research question as a mathematical Chemistry question. Sand is essentially silica (SiO2), which (in my one internet search) has a density of 2.65 g/cc. 0.5 mm is 0.05 cm. A cube with a side of 0.5 mm would therefore have a volume of (0.05 cm)^3 = 0.000125 cc. The mass of this grain would be m=dV or m= 0.000125 × 2.65 = 0.00033125 g. The number of moles is the number of grams divided by the molar mass of SiO2, (which is 60.0835 g/mol), so mol = 0.00033125/60.0835 = 5.51316 × 10^(-6) mol. The number of formula units is Avogadro's number times the number of moles, or (6.022 × 10^23) × (5.51316 × 10^(-6)) = 3.320 × 10^18 formula units. There is one silicon atom per formula unit, and two oxygen atoms per formula unit in SiO2, so:
Number of silicon atoms = 3.320 × 10^18
Number of oxygen atoms = 6.640 × 10^18
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