Simply Latin for 'right hand'. How it ended up as a nerd I can't say, my slang dictionary doesn't have it, and applying to most of the population would seem a pointless nickname unless someone only had the one hand in which case it would make sense.
edited to add:
Just saw the first reply (crossed with mine), I knew the cartoon character but didn't realise it was the first one.
Probably misspelled.
But a combination of the two words poignant, meaning keen or strong in mental appeal
and
dexter, meaning on the right side
seems to make sense.
His very intelligent right hand man.
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