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Angelman Syndrome Trivia Quiz

This quiz is about the rare genetic disorder Angelman syndrome. By taking this quiz, you will learn about a disorder which you most likely know nothing about.

A multiple-choice quiz by weloveum. Estimated time: 6 mins.

Author
weloveum

Time
6 mins

Type
Multiple Choice

Quiz #
131,794

Updated
Dec 03 21

# Qns
15

Difficulty
Difficult

Avg Score
7 / 15

Plays
1024

One at a Time - Single Page - Timed Game

Question 1 of 15

1. Who was the pioneer in the discovery of Angelman syndrome? Hint

Dr. Howard M. Forrester

Dr. Elijah Hewlett

Gregor Mendel

Dr. Harry Angelman

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Question 2 of 15

2. Angelman syndrome was first referred to as: Hint

Cinderella syndrome

Happy Puppet syndrome

Hewlett's disorder

All Saint's syndrome

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Question 3 of 15

3. What Disney character was thought by some to have been modeled after someone with Angelman syndrome?

Answer: (One Word)

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Question 4 of 15

4. What is the hallmark manifestation of Angelman syndrome? Hint

having good behavior

somnolence

being non-ambulatory

having a lack of speech

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Question 5 of 15

5. Which chromosome is affected in Angelman syndrome?

Answer: (one word or number)

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Question 6 of 15

6. What is considered the sister disorder of Angelman syndrome? Hint

Cherub disease

Dyscalculia

Huntington disease

Prader-Willi syndrome

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Question 7 of 15

7. What is the most common genetic transmission of Angelman syndrome? Hint

UPD

Deletion positive

Trisomy

Translocation

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Question 8 of 15

8. What does the abbreviation "UPD" represent? Hint

uniparental disomy

ubiquitous patterned disorder

unified paternal distortion

usurian parsimile deletion

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Question 9 of 15

9. Which of the following is a common characteristic of Angelman syndrome? Hint

excessive interest in bright light

lack of hair growth

abnormal fascination with water

closely spaced teeth

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Question 10 of 15

10. Which of the following would be considered common to the facies of individuals with Angelman syndrome? Hint

flat facial profile

prognathism

cryptorchidism

atresia choanae

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Question 11 of 15

11. Which of the following is the closest estimate of the prevalence of Angelman syndrome? Hint

1 in 500,000

1 in 100,000

1 in 15,000

1 in 50,000

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Question 12 of 15

12. Using an MRI or CT Scan, normal brain structure can be found in individuals with Angelman syndrome.

True

False

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Question 13 of 15

13. Which of the following is a genetic test used to determine whether or not an individual has Angelman syndrome? Hint

PAPA

TREE

FISH

CAT

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Question 14 of 15

14. In North America, which race has the highest incidence of Angelman syndrome? Hint

Black

Native American

There is no difference among races.

White

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Question 15 of 15

15. Angelman syndrome is commonly misdiagnosed as which of the following? Hint

Down syndrome

Cystic fibrosis

Fragile X syndrome

Cerebral palsy

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Quiz Answer Key and Fun Facts

1. Who was the pioneer in the discovery of Angelman syndrome?

Answer: Dr. Harry Angelman

Dr. Harry Angelman first described Angelman syndrome in 1965.

2. Angelman syndrome was first referred to as:

Answer: Happy Puppet syndrome

Angelman syndrome was first called Happy Puppet syndrome due to the characteristic of individuals with this disorder moving like a marionette.

3. What Disney character was thought by some to have been modeled after someone with Angelman syndrome?

Answer: Dopey

Dopey's characteristics of not speaking, having a small head, having a happy demeanor, and moving like a marionette are all common manifestations of Angelman syndrome.

4. What is the hallmark manifestation of Angelman syndrome?

Answer: having a lack of speech

Typically, individuals with Angelman syndrome have no or minimal verbal language. Receptive language is much greater than expressive.

5. Which chromosome is affected in Angelman syndrome?

Answer: 15

Although there are four types of transmissions, chromosome 15 is always involved in the transmission of Angelman syndrome.

6. What is considered the sister disorder of Angelman syndrome?

Answer: Prader-Willi syndrome

The fifteenth chromosome is also affected in Prader-Willi, but the transmission and the manifestations are different. The difference in transmission is that as opposed to the maternal part of chromosome being affected in Angelman syndrome, the paternal contribution is affected in Prader-Willi. Common characteristics of Prader-Willi include a short stature, obesity, mental retardation, and behavior problems.

7. What is the most common genetic transmission of Angelman syndrome?

Answer: Deletion positive

The most common transmission of Angelman syndrome, occurring in 80% of cases, results from a deletion in chromosome #15q11-13(maternal). A deletion occurs when a portion of the genes on a chromosome are missing.

8. What does the abbreviation "UPD" represent?

Answer: uniparental disomy

UPD refers to the genetic transmission of uniparental disomy-two copies of one parent's chromosome, and none from the other.

9. Which of the following is a common characteristic of Angelman syndrome?

Answer: abnormal fascination with water

An interesting characteristic of most individuals with Angelman syndrome is fascination with water, which leads to an increased risk of drowning.

10. Which of the following would be considered common to the facies of individuals with Angelman syndrome?

Answer: prognathism

Prognathism is abnormal forward projection of the jaw.

11. Which of the following is the closest estimate of the prevalence of Angelman syndrome?

Answer: 1 in 15,000

Different studies have produced results from 1 in 10,000 to 1 in 20,000.

12. Using an MRI or CT Scan, normal brain structure can be found in individuals with Angelman syndrome.

Answer: True

Although the structure of the brain is normal, it does not carry out all of its functions correctly.

13. Which of the following is a genetic test used to determine whether or not an individual has Angelman syndrome?

Answer: FISH

FISH, or fluorescent in situ hybridization, detects a deletion on chromosome 15. It is much more specific and more helpful in detecting Angelman syndrome than the typical chromosome test (a karyotype).

14. In North America, which race has the highest incidence of Angelman syndrome?

Answer: White

There have been reports of Angelman syndrome all around the world and in many different races. In North America, though, the largest portion of individuals with Angelman syndrome are of the white race.

15. Angelman syndrome is commonly misdiagnosed as which of the following?

Answer: Cerebral palsy

Common characteristics of cerebral palsy which are also common in Angelman syndrome include a happy affect, ataxia (impared ability to coordinate movement), and feeding difficulty. There are currently massive efforts to make everyone, both health-care professionals and lay people, familiar with Angelman syndrome. If you would like to learn more about Angelman syndrome, visit www.angelman.org

Source: Author weloveum

This quiz was reviewed by FunTrivia editor crisw before going online.
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