Answer: Uncle Buck
Other taglines included "OH NO! IT'S...(Uncle Buck)" and "Getting rid of intruders was tough. But here's a menace that's coming to stay".
The list of actors considered for the role of Uncle Buck reads like a Hollywood Who's Who. They included John Goodman, Danny DeVito, Ed O'Neill, Dan Aykroyd, George Wendt, Michael Keaton, Robin Williams, Jack Nicholson, Joe Pesci, Bill Murray, Jim Belushi, Dudley Moore, John Travolta, Tom Hanks, Dan Aykroyd, Chevy Chase, Tim Allen, Jim Carrey, and Tom Cruise. (Yes, Tom Cruise - can you imagine Tom Cruise as Uncle Buck? No, I can't either).