25. Science Fiction. This 1968 science fiction film had three parts to it, "The Dawn Of Man", "Jupiter Mission" and "Jupiter and Beyond the Infinite". It featured Keir Dullea and was directed by Stanley Kubrick.
From Quiz AFI's 10 Top 10
Answer:
2001: A Space Odyssey
"2001" was about a space station that could think for itself and tried to eliminate the people aboard. The other science fiction film on the list were "Star Wars Episode IV: A New Hope", "E.T. The Extra-Terrestrial", "A Clockwork Orange", "The Day The Earth Stood Still", "Blade Runner", "Alien", "Terminator 2: Judgment Day", "Invasion Of The Body Snatchers" and "Back To The Future", respectively.