63. George III (1738-1820), King of England, was known to be "mad" and delusional. Do you know what disease he actually suffered from?
From Quiz Mental Illness in History
Answer:
porphyria
George III, the third Hanoverian monarch and the first born in England, was the father of fifteen children. His mental illness exhibited itself early on in his reign, which began in 1760. One day in 1788, he attacked his oldest son, trying to smash his head against a wall. According to witnesses, during this episode George was foaming at the mouth and his eyes were bloodshot. The king was placed in a straight-jacket and eventually a special iron chair designed for restraint. Records show that he suffered periods of intense gloom broken by spells of cheerfulness, which sound a lot like what would be called bipolar disorder today. It is thought that George suffered from porphyria, a rare genetic disorder which interferes with the body's chemical balance; untreated, it can cause insanity. The symptoms, which include rashes, abdominal pain, and reddish blue urine, were all exhibited by him. By April 1789, George's doctors announced him "cured" of his madness; however, he continued to suffer from poor health and had further mental breakdowns in 1801 and 1804. In 1810 George's insanity became permanent, after which his son George took over his kingly duties. George III died on January 29, 1820, blind, deaf and insane at Windsor Castle.